Switching from Wegovy to Mounjaro: What You Should Know
If you’re considering switching from Wegovy to Mounjaro, you’re not alone. Many people want to know how these two weight‑loss medications compare, and how to make the change safely.
Disclaimer:
This information is provided for general educational purposes only and is not medical advice. Always speak with a qualified healthcare professional before making any changes to your medication, including switching from Wegovy to Mounjaro. Guidance may differ depending on your personal health circumstances.
Can You Switch from Wegovy to Mounjaro?
No, you cannot switch directly.
You’ll need a short break before starting Mounjaro:
- Lower Wegovy dose (under 1 mg): Pause for 2 weeks
- Higher Wegovy dose (over 1 mg): Pause for 4 weeks
During this time, weight loss may slow — but you’ll restart progress with Mounjaro.
Which Is More Effective: Wegovy or Mounjaro?
- Wegovy: Around 15% average weight loss
- Mounjaro: Up to 22% average weight loss
Answer: Studies suggest Mounjaro may be more effective than Wegovy for weight loss.
Do Wegovy and Mounjaro Have the Same Side Effects?
Yes, they share common side effects:
- Nausea
- Constipation
- Diarrhea
Key difference: Mounjaro’s slower dose increases may make side effects easier to tolerate.
Does Mounjaro Affect Birth Control Pills?
Yes.
Mounjaro may reduce the effectiveness of oral contraceptives. Your doctor may recommend another method of contraception.
How Is Mounjaro Different from Wegovy?
Here’s a quick breakdown:
- Hormones:
- Wegovy → GLP‑1
- Mounjaro → GLP‑1 + GIP
- Dosing schedule:
- Wegovy → Increase every 4 weeks (If required)
- Mounjaro → Increase every 4 weeks (If required)
- Effectiveness:
- Wegovy → About 15% body weight
- Mounjaro → Up to 22% body weight
- Side effects: Both similar, but Mounjaro may be easier to tolerate
Stop Wegovy Safely, You don’t Just Swap!
- Therefore, you should always consult your prescriber.
- Taper gradually to reduce side effects
- If side effects are strong, your doctor may recommend an even slower taper
How to Start Mounjaro After Wegovy
Typical starting plan (with adjustments for tolerance):
- Weeks 1–4: Begin with 2.5 mg once a week
- Weeks 5–8: If you’re tolerating side effects well, increase to 5 mg weekly
- After that: Every 4 weeks, you may increase by 2.5 mg — but only if side effects remain manageable
- Important: If you’re still experiencing significant nausea or other side effects, stay on your current dose longer before moving up
The goal is not to reach the highest dose quickly, but to find the lowest dose that gives results without difficult side effects.
Other Things to Consider Before Switching
- Heart health: Wegovy has proven benefits for heart disease. Mounjaro’s heart results are still under study in the UK.
- Contraception: Consider alternatives to the pill if starting Mounjaro.
- Long‑term use: Both medications are designed for ongoing treatment.
Wegovy vs. Mounjaro: Quick Comparison
| Feature | Wegovy | Mounjaro |
|---|---|---|
| Hormones targeted | GLP‑1 | GLP‑1 + GIP |
| Dose escalation | Every 4 weeks | Every 6 weeks |
| Weight loss | ~15% body weight | ~22% body weight |
| Heart benefits | Proven | Not yet confirmed |
| Contraception impact | None | May reduce pill effectiveness |
Final Takeaway: Switching from Wegovy to Mounjaro
Finally, switching doesn’t have to be complicated. With medical guidance and the right timing, you can move from Wegovy to Mounjaro safely.
Remember:
- Take a 2–4 week break, depending on your Wegovy dose
- Start Mounjaro gradually with your doctor’s plan
- Be mindful of contraception and heart health
With careful planning, Mounjaro may help you lose more weight and manage side effects better than Wegovy.